NAD+ is an abundant molecule that plays a critical role in hundreds of processes which keep your cells healthy, and has a significant impact on many regulatory pathways of immunity.

The older you get, the more NAD+ is needed to help repair and power your cells, which leads to a decline in NAD+ levels as you age.
Maintaining NAD+ levels benefits your entire body.
It is essential for your immune system to fight against infection, acute inflammation and chronic inflammation.
It is also vital to mitochondrial energetic processes like ATP production and DNA repair, and protects against most hallmarks of aging.
NAD+’s abundance in the body has been shown to be critical to essential biological functions such as:


NAD+ decline and chronic inflammation have long been separately associated with aging and age-related disease.

Recent research has shown that the two phenomena are linked, and that chronic inflammation is actually a driver of NAD+ decline.

Scientists have known for some time that NAD+ levels decrease with age, but it has not been clear whether this is because not enough NAD+ is being manufactured, or because the NAD+ itself is somehow degrading.

Recent findings from one of our key research partners, the Buck Institute for Research on Aging, show that the cause is both.
NAD+ degradation like this can lead to lowered cellular energy production, weakened cellular metabolism and less active sirtuins, which have widespread anti-aging properties.

How does inflammation

cause NAD+ decline?

Senescent cells, which stop dividing in response to DNA damage (a hallmark of aging), release inflammatory proteins. As senescent cells build up in tissues over the course of a lifetime, they trigger chronic inflammation.

This inflammation results in the expression of a protein called CD38 (cyclic ADP ribose hydrolase), which in turn degrades NAD+

New opportunities for

NAD+ boosting

Currently, the most common way to replenish the body’s NAD+ is by supplementing with intermediates like NMN, which helps to support cell survival and regulate inflammation.

With research showing that blocking CD38 activity in older animals restores NAD+ levels in specific tissues, there is now an opportunity to create therapeutic interventions that prevent degradation of NAD+
Combining both approaches to healthy NAD+ levels – boosting and preventing its degradation – will enable us to attack on two fronts in the fight against aging and age-related disease.