THE ROLE OF NAD+
NAD+ is an abundant molecule that plays a critical role in hundreds of processes which keep your cells healthy, and has a significant impact on many different regulatory pathways of immunity.

The older you get, the more NAD+ is needed to help repair and power your cells, which leads to NAD+ levels decline with age.

Maintaining NAD+ levels benefits your entire body. It is essential for immune defense against viruses and bacteria, vital to mitochondrial energetic processes like ATP production and DNA repair, and protects against the hallmarks of aging.

NAD+’s abundance in the body is critical to essential biological functions:

    • Energy creation
    • DNA repair
    • Neurogenesis
    • Inflammation
    • Immune response
    • Muscle repair
    • Cardiovascular function
    • Cellular signaling
NMN AS AN NAD+ PRECURSOR
NMN is a molecule that occurs naturally in all life forms. It fuels essential functions of cells, such as how they generate energy and protect and repair our bodies, by generating a vital molecule called NAD+.

As the final step in the biochemical chain reaction that produces NAD+, NMN is a highly efficient route to generating NAD+ levels, which in turn supports vital molecular pathways that keep your body running well.

Some common natural foods like broccoli or avocado contain NMN, but not enough to meet your ongoing and growing needs. Vegetables and fruits like broccoli, cabbage and avocado contain around 1 mg NMN/100 g, far from the 300 to 600 mg a day your body needs in general.

Supplementing with NMN is a highly effective way to naturally boost your NAD+ levels and counter reductions as you get older, helping you maintain the essential elements of your vitality: brain and body energy, focus and immunity.

A key beneficiary of the NAD+ boosting properties of NMN is immunity – your body’s defense system – which tends to get weaker with age. When you age, you can get sick more easily, and it becomes harder to recover from injuries and infection.

NMN helps boost immunity to protect against chronic inflammation that comes with aging,  acute inflammation caused by stressors and infection :
. Chronic inflammation is responsible for accelerating the process of biological aging and worsening many age-related diseases.
. Acute inflammation is caused by common stressors such as intense exercise, lack of sleep, pollutants, nervous tension, sun exposure and other stressing lifestyle factors.
. The primary function of your immune system is to defend your body against viruses and bacteria.

INFLAMMATION DRIVES DECLINE IN NAD+
NAD+ decline and chronic inflammation have long been separately associated with aging and age-related disease. Recent research has shown that the twophenomena are linked, and that chronic inflammation is actually a driver of NAD+ decline.

NAD+ decline and degradation

Scientists have known for some time that NAD+ levels decrease with age, but it hasnot been clear whether this is because not enough NAD+ is being manufactured, or because the NAD+ itself is somehow degrading.

Recent findingsfrom one of our key research partners, the Buck Institute forResearch on Aging, show that the cause is both.

How doesinflammation cause NAD+ decline?

Senescent cells,which stop dividing in response to DNA damage (a hallmark of aging),release inflammatory proteins. As senescent cells build up in tissuesover the course of a lifetime, they trigger chronic inflammation.
This inflammation results in the expression of a protein called CD38 (cyclic ADP ribose hydrolase), which in turn degrades NAD+.

NAD+ degradation like this can lead to lowered cellular energy production, weakened cellular metabolism and less active sirtuins, which have widespread anti-aging properties.

New opportunities for NAD+ boosting

Currently, the most common way to replenish the body’s NAD+ is by supplementing with intermediates like NMN, which helps to support cell survival and regulate inflammation.

With research showing that blocking CD38 activity in older animals restores NAD+ levels in specific tissues, there is now an opportunity to create therapeutic interventions that prevent degradation of NAD+ caused by inflammation.

Combining both approaches to healthy NAD+ levels – boosting and preventing its degradation – will enable us to attack on two fronts in the fight against aging and age-related disease.